DENV-Ab DB

13D4-1

Host: Murine		Isotype: igG2a
Infection: Primary		PubMed: 1698924
Immunogen: Whole virus DENV-2
Selection: Whole virus DENV-2, human

E protein epitope map

Whole virus epitope map

Activity

Specificity	Neutralizing	Assay Type	Activity Type	Units	DENV-1	DENV-2	DENV-3	DENV-4	PubMed
SpecificityComplex	Neutralizingyes	Assay TypeBinding	Activity TypeFC, Raji-DC-SIGN-R	Unitsqualitative	DENV-1+	DENV-2+	DENV-3+	DENV-4+	PubMed17881453

Epitope

Method	Epitope Type	Organism	Strain	Protein	Domain	Sequence	PubMed
MethodComputational	Epitope TypePredicted	Organism	Strain	ProteinE(AC)	Domain	Sequence101,107,145,147....	PubMed
MethodMutagenesis	Epitope TypeResidue	OrganismDENV-2	StrainThailand/16681/84	ProteinE	DomainD3	Sequence315,317,331,359	PubMed17881453

Database last updated on 5 December, 2016.

This research was conducted in conjunction with the Telemedicine and Advanced Technology Research Center (TATRC), Military Infectious Diseases Research Program (MIDRP), and US Army Medical Research and Development Command (USAMRDC).

E protein epitope map description
This epitope map visualizes all epitope residues associated with the mAb on to the structure of the DENV E protein. Epitope residues are depicted as spheres, colored according to domain, and with a size corresponding to the epitope resolution, for domain, peptide, and residue-level epitopes.

Whole virus epitope map description
This whole-virus depiction of the dengue virus envelope maps experimentally identified epitope residues and corresponding predicted quaternary epitopes colored in accordance with three different icosahedral symmetry environments on to the viral surface.