14A4

Murine          IgG
Primary            23453578
Whole virus DENV-3
Whole virus DENV-3, E domain III
       
E protein epitope map
E protein epitope map description
This epitope map visualizes all epitope residues associated with the mAb on to the structure of the DENV E protein. Epitope residues are depicted as spheres, colored according to domain, and with a size corresponding to the epitope resolution, for domain, peptide, and residue-level epitopes.
Whole virus epitope map
Whole virus epitope map description
This whole-virus depiction of the dengue virus envelope maps experimentally identified epitope residues and corresponding predicted quaternary epitopes colored in accordance with three different icosahedral symmetry environments on to the viral surface.

Activity

SpecificityNeutralizingAssay TypeActivity TypeUnitsDENV-1DENV-2DENV-3DENV-4PubMed
ComplexyesNeutralizationFRNT50, Veroug/mL10.511.012.011.023453578
Type-specific DENV-3yesBindingSingle-point ELISAqualitative--+-20333252

Epitope

MethodEpitope TypeOrganismStrainProteinDomainSequencePubMed
ComputationalPredictedE(AC)147-148,167,300....
MutagenesisResidueDENV-3CH53489ED3308,326,32820333252
Database last updated on 5 December, 2016.